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Study summary

Mazdutide in phase 3: what the obesity trial reported

A dual GLP-1 and glucagon receptor agonist completed a large phase 3 trial in China. Here is what the researchers measured, in plain English.

Veritide Research · 10 October 2026 · 5 min read

Illustration of peptide chains and cell-surface receptors
Simplified scientific illustration — not an image from the study.

Mazdutide is a lab-made peptide designed to act on two hormone receptors involved in appetite and energy use: GLP-1 and glucagon. It has moved further through clinical testing than most peptides discussed online.

What the trial looked at

  • The GLORY-1 phase 3 trial enrolled Chinese adults with overweight or obesity and compared mazdutide groups with a placebo group over 48 weeks.
  • The investigators reported larger average reductions in body weight in the mazdutide groups than in the placebo group.
  • They also reported changes in waist size, blood pressure and blood fats as secondary measures.
  • Stomach-related side effects — nausea, diarrhoea and vomiting — were the most common, and were described as mostly mild to moderate.

What it does not tell us

The trial ran in one country, in a defined group of adults, under medical supervision with pharmaceutical-grade material. Long-term outcomes such as heart health were not the main question, and results in other populations had not been published at the time of writing.

Mazdutide is not licensed as a medicine in the United Kingdom. It holds no MHRA marketing authorisation and is not approved for human or animal use.

Compounds referenced

Reference profiles: mechanism, published evidence and UK regulatory status.

Compound profileMazdutideDual GLP-1 / glucagon receptor agonist · Phase 3 results reported in Chinese study groupsCompound profileRetatrutideTriple incretin receptor agonist · Phase 2 results published; phase 3 trials under way

Reference materials mentioned here

For laboratory research use only. Not a medicine and not for human or animal use.

MazdutideResearch materialMazdutide£89.99View listing ›RetatrutideResearch materialRetatrutide£94.99View listing ›

Veritide does not sell or supply anything. This links to a third-party UK laboratory supplier; we may earn a commission if you buy through it, at no extra cost to you. Materials are sold for laboratory research use only and are not licensed medicines.

Sources

Published for research and educational reference only. Not medical advice. No dosing, administration or acquisition guidance is provided.

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