IGF-1 LR3

What it is

IGF-1 LR3 is a chemically altered version of insulin-like growth factor 1, a hormone the liver makes in response to growth hormone. The changes make it bind less to carrier proteins.

It was created as a laboratory reagent for growing cells, and that is where nearly all published use sits.

How researchers think it works

Papers described it activating the IGF-1 receptor, which is involved in cell growth and division.

What has research seen in people?

There is no human research on this modified version at all — its published use is as a laboratory reagent for growing cells.

Human trials exist only for the unmodified hormone, which is a licensed medicine for a rare growth disorder.

Researchers have raised general concerns about pushing growth-factor signalling, because it drives cell division.

Where this material is listed

For laboratory research use only. Not a medicine and not for human or animal use.

Research materialIGF-1 LR3£45.99View listing ›

Veritide does not sell or supply anything. This links to a third-party UK laboratory supplier; we may earn a commission if you buy through it, at no extra cost to you. Materials are sold for laboratory research use only and are not licensed medicines.

What studies have found

• Published work is almost entirely cell-culture research, where it was used to sustain cell growth in the laboratory.
• Human trials exist for the unmodified hormone as a licensed medicine for a rare growth disorder, but not for this modified analogue.

What we still do not know

• No human trials of this analogue have been published, so nothing about effects or safety in people is established.
• Researchers have raised concerns about growth-factor signalling and cell proliferation in general.

Sources

• PubMed — long R3 IGF-1 literature index ›